Grape seed extract suppresses calcitonin gene-related peptide secretion and upregulates expression of GAD 65/67 and GABAB receptor in primary trigeminal ganglion cultures

The trigeminal ganglion is implicated in the underlying pathology of migraine and temporomandibular joint disorders (TMD), which are orofacial pain conditions involving peripheral and central sensitization.The neuropeptide calcitonin gene-related peptide (CGRP) is synthesized in some trigeminal ganglion neurons, keychron m4 and its release promotes

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IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy

Abstract Tissue-resident Natural Killer (trNK) cells are crucial components bostik universal primer pro of local immunity that activate rapidly upon infection.However, under steady state conditions, their responses are tightly controlled to prevent unwanted tissue damage.The mechanisms governing their differentiation and activation are not fully un

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Does Increasing Natural Gas Demand in the Power Sector Pose a Threat of Congestion to the German Gas Grid? A Model-Coupling Approach

This study aims to investigate the possible congestion in the German natural gas system, which may arise due to an increase in the gas consumption in the power sector in extreme weather events.For this purpose, we develop a two-stage bostik universal primer pro approach to couple an electricity model and a natural gas network model.In this approach

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